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A 45 year old man with alcoholism is prescribed disulfram by the addictions clinic medical staff. Which of the following is true regarding the drug?
A. Takes 2 hours to work after alcohol
B. Hypothyroidism is associated
C. Levels of circulating acetaldehyde are decreased
D. Use of metronidazole can precipitate psychosis
E. Metabolism of phenytoin is increased
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E. Metabolism of phenytoin is increased
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D. Use of metronidazole can precipitate psychosis is so tempting
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acute alcohol intake inhibits metabolism of drugs ,while chronic alcohol intake induces drug action...so it will in duce phenytoin metabolism
alcohol will induce disulfiram like reaction with metronidazole
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well, confusing between d and e, good question ulise keep posting
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Answer: d) use of metronidazole can precipitate psychosis. Disulfiram (antabuse) acts by causing raised acetaldehyde levels. This causes unpleasant effects. Metronidazole and disulfram synergism may lead to psychosis.
