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Biochem Q - jumpingjack
#1
A group of investigators studies the mechanism of catecholamine synthesis regulation.In animal experiments hypophysectomy induced a decrease in epinephrine secretion by the adrenals.Decrease activity of which of the following enzymes is most likely responsible for the effect observed?
a-Phenylalanine hydroxylase
b-Tyrosine hydroxylase
c-Dopa decarboxylase
d-Dopamine beta hydroxylase
e-Phenylethanolamine n-methyltransferase
f-Catechol-methyltransferase
g-Monoamine oxydase
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#2
come on guys give it a shot
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#3
well, let the investigator worry about the q. too hard for us...

ok, just kidding

really, not much idea. why it has something to do with hypophysectomy?? twist coming??

I only know in adrenal, you coulud use e-Phenylethanolamine n-methyltransferase to convert NE to epinepherine.

but in this case, do not know.

Maybe still EEEEE
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#4
e-Phenylethanolamine n-methyltransferase??
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#5
ans seems E ..but may be rate limiting enzyme B
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#6
EEEEEEEEEE....for sure
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#7
it's E
http://www.metabolismjournal.com/article...8/abstract

it says that high levels of glucocorticoids are required for the induction of PNMT for conversion to epinephrine. This makes sense that after hypophysectomy, lack of glucocoticoids will lead to decreased activity of PNMT , hence decreased epinephrine.
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#8
This question is on UW and explains really cool and almost like My2k said
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#9
Good job quansar and others
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