04-04-2007, 12:31 PM
Which leukemia is characterized by a translocation between chromosome 15 and 17, and commonly presents with leukopenia and has been associated with DIC ?
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Qn: Leukemia? - question
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04-04-2007, 12:41 PM
Yes. You rock... AML-M3- Acute promyelocytic leukemia
04-04-2007, 01:30 PM
Can anyone tell us the mechanism of this Promyelocytic leku?
04-04-2007, 02:57 PM
Here is the high yeild information on Acute Myelogenous Leukemia (AML):
Epidemiology:Occurs most frequently in middle-aged adults. Risk factors include Down syndrome. Exposure to ionizing radiation. Benzene. Chemotherapy (risk factor). Associated with chromosomal translocations: M3, t(15;17); M2, t(8;21). There are 7 subgroups (M1-M7), each associated with a specific neoplastic myeloid lineage (myelocyte,monocyte,megakaryocyte erythrocyte) and a level of maturation. M1:Myeloblastic (without maturation). M2: Myeloblastic (with maturation). M3  romyelocytic.M4: Myelomonocytic. M5:Monocytic. M6:Erythroleukemia. M7:Megakaryocytic. Bone Marrow: Hypercellular with distorted architecture. Myeloblasts specific to the subtype. Auer rods (cytoplasmic granules) especially with M3 (acute promyelocytic leukemia). Pancytopenia with myeloblasts. Fatigue due to anemia. Infection due to low WBCs. Bleeding (menorrhagia , nose bleeds) due to thrombocytopenia. Hepatosplenomegaly. Treatment: Chemotherapy. Bone marrow transplant. All-trans retinoic acid for M3 with t( 15:17). Prognosis: Fair. 60% remission, but only 25% of these patients remain disease free for 5 years. Good luck friends! |
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