anca -

[ArchivalUser]

xyz

what are the conditions ANCA appear?
what does the C-ANCA & P-ANCA (perinuclear)pattern of the antibodies indicate?

[ArchivalUser]

salbato

hi
ANCA ,are antineutrophil auto antibody.there are basically two patterns based on the immunofluorescent patterns of staining of ethanol fixed neutrophils,
cytoplasmic localizarion of the staining means C-ANCA and the usaul antigen in this case is proteinace 3.The second is perinuclear staining pattern and the target antigen is myeloperoxidase.
Generally speaking ANCAs are auto antibody found in a number of immune mediated diseases expecially the vasculitides.type 3 rapidly progressive glomerulonephritis,primary sclerosing cholangitis.
wegeners granulomatosis is associated with c-ANCA while p-ANCA is associated with microscpopic polyangitis,churg-strauss,primarysclerosisng cholangitis and some books still associate P-anca with polyarteritis nodosa,but latest edition of Robbins says no association with p-ANCA.

[ArchivalUser]

zed

The antineutrophil cytoplasmic antibody (ANCA) associated systemic vasculitides include Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and necrotizing crescentic glomerulonephritis.[3] Two distinct ANCAs have been noted. C-ANCAs bind to the antigen proteinase 3 and result in a diffuse cytoplasmic staining pattern on immunofluorescence and are highly associated with Wegener's granulomatosis, while p-ANCAs bind to myeloperoxidase, have a perinuclear staining pattern, and are associated with microscopic polyangiitis and Churg-Strauss syndrome. ELISA studies available for both antibodies are useful to confirm the antigenic specificity and quantitate the ANCA when immunofluorescence shows either this diffuse or perinuclear staining pattern.