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Two bone marrow aspirates are studied under the microscope. One is taken from an adult with Hemoglobin SS disease (sickle cell anemia) and the other is from an adult with normal Hemoglobin A. The marrow aspirate from the patient with sickle cell anemia could be identified due to its increased
A. fat
B. iron stores
C. medullary bone
D. megakaryocytes
E. myeloid:erythroid ratio
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ddddddddddddddd
IT COULD NOT BE E as i think the ratio remains constant
its correction of reticulocyte count by bone marrow
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Explanation:
The correct answer is B. Adults with sickle cell disease have undergone decades of accelerated RBC formation and destruction, leading to accelerated erythropoiesis in the bone marrow. Consequently the bone marrow becomes hyperplastic, with marked increases in the number of normoblasts (erythroblasts) at the expense of
marrow fat and marrow bone (choices A and C). Although the white cell and megakaryocyte lines are
undiminished (choices D and E), there is a marked increase in RBC precursors and iron stores. Iron storage
increases as a consequence of both chronic transfusions and increased dietary absorption; these increased
iron stores can be appreciated with a Prussian blue stain.
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well.. d can`t be wrong either.hemolytic diseases produce a hyperplastic marrow increasing all blood elements isn`t it?
