neuro quiz - target99

[ArchivalUser]

3. An 80-year-old woman dies after a long history of progressive memory loss, apraxia, and recurrent episodes of
confusion. In the last months of life she was bedridden and unable to recognize familiar faces and objects. The
pathologist identifies numerous flame-shaped intracytoplasmic inclusions in neurons of the neocortex and
hippocampus. These consist of paired helical filaments (PHFs) on electron microscopy. Which of the following
biochemical changes most likely accounts for the development of PHFs in this condition?
A. Abnormal degradation of amyloid precursor protein (APP)
B. Abnormal phosphorylation of tau
C. Accumulation of advanced glycosylation end (AGE) products
D. Increased expression of APP
E. Precipitation of insoluble a-tubuli

[ArchivalUser]

b.alzimers

[ArchivalUser]

bb tau protein abnormal phosphorylation

[ArchivalUser]

ee

[ArchivalUser]

GOOD
always remember AMITABH BACCHAN OF MOVIE BLACK
alzeimers diease "TAUJI".........LOL

[ArchivalUser]

have not seen this movie yet thanks for analogy btw.

[ArchivalUser]

nice comparision...thanx target99

[ArchivalUser]

but target99 can u tell us abtt Tau ...
concept ....not very clear,,..
thanks

[ArchivalUser]

well in alzemiers disease which is related to related to amyloid deposition gene of which is located on the chromosme no 21 DEPOSITS ARE PRESENT IN THE INTRACELLULAR AND EXTRACELLULAR COMPARTMENTS

IN INTRACELLULAR --------------> we have abnormally phosphorylated TUA protein
it is only in the INTRACELLULAR COMPARTMENTSA THAT THE "NFT" are found
IN EXTRACDELLULAR----------->have beta amyloid core

[ArchivalUser]

thanks target99