pharm question 9 - pepsi00

[ArchivalUser]

You want to maintain an average plasma concentration of 10 mg/liter. What dose would you adminster every 3 hours if the volume of distribution is 20 liters and the elimination half life is 6 hours?

A. 23 mg
B. 70 mg
C. 140 mg
D. 1,200 mg
E. Cannot determine from the information provided

explain thanks

[ArchivalUser]

aaa

[ArchivalUser]

maintenance dose = Css * Cl = Css * (0.7 *Vd / t1/2) = 70/3 =23

[ArchivalUser]

wait, forgot the dosing interval, so it should be Css * Cl * dosing interval = 70
bbb

[ArchivalUser]

dont understand your calculation. be more explicit, step by step

[ArchivalUser]

anyone else?