06-14-2008, 09:43 AM
48) A 63 yrs old woman with 5 yrs history of type 2 diabetes mellitus comes to the physician for a routine exam. She notes that her blood glucose concentration has been persistently higher over the past 4 months since she gained 9 kg during the holidays. Her diabetes mellitus has been more difficult to control because weight gain causes which of the following to occur?
A) downregulation of insulin receptors
B) increased activity of hepatic glucokinase
C) increased expression of GLUT-4 transporters
D) inhibition of insulin release
E) upregulation of insulin signaling
A) downregulation of insulin receptors
B) increased activity of hepatic glucokinase
C) increased expression of GLUT-4 transporters
D) inhibition of insulin release
E) upregulation of insulin signaling