qn - maverick26

[ArchivalUser]

a infant is know to have def of variety of the mitochondrial enzymes.a common subunit of lipoic acid is abnormal in these enzymes..pt is likely to have which of the following?
a.citrullinemia
b.lactic acidosis
c.homocysteinuria
d.methlymalonic aciduria
e.orotic aciduria

[ArchivalUser]

bb

[ArchivalUser]

b.lactic acidosis

[ArchivalUser]

B. PDH require Thiamina(B1), Lipoci Acid, CoA, FAD (from B2), Niacin(From B3), and it is located in the mitochondria.

[ArchivalUser]

lipoic acid, cofactor for some TCA enzymes including PDH--->lactic acidosis. same as thiamine

[ArchivalUser]

yup lactic acidosis it is