09-02-2009, 11:41 AM
never knew this...
A mutation in the fibrillin gene is the cause of Marfan syndrome notable for tall patients with severe nearsightedness, lens subluxation, arachnodactyly, hyperextensible joints, and risk of aortic dissection. It is thought to be due to unopposed action of TGF-beta (since fibrillin inhibits TGF-beta in normal patients).
A mutation in the fibrillin gene is the cause of Marfan syndrome notable for tall patients with severe nearsightedness, lens subluxation, arachnodactyly, hyperextensible joints, and risk of aortic dissection. It is thought to be due to unopposed action of TGF-beta (since fibrillin inhibits TGF-beta in normal patients).
