q4 - sps

[ArchivalUser]

The elimination of a drug is described as being heavily dependent on Phase II metabolic reactions. Which of the following is a Phase II reaction as far as drug elimination goes?

a. Glucuronidation
b. Deamination
c. Ester hydrolysis
d. Nitro reduction
e. Sulfoxide formation

[ArchivalUser]

A

[ArchivalUser]

A: no change in basic structure of molecule.

[ArchivalUser]

AA

[ArchivalUser]

uppp

[ArchivalUser]

Thanku basicq

The answer is: A

Biotransformation reactions involving the oxidation, reduction, or hydrolysis of a drug are classified as Phase I (or nonsynthetic) reactions; these reactions may result in either the activation or inactivation of a pharmacologic agent. There are many types of these reactions; oxidations are the most numerous. Phase II (occasionally called synthetic) reactions,which almost always result in the formation of an inactive product, involve conjugation of the drug (or its derivative) with an amino acid, carbohydrate, acetate, sulfate”or glucuronic acid as noted in the question. The conjugated form(s) of the drug or its derivatives may be more easily excreted than the parent compound.