06-26-2005, 11:01 AM
in GD pt, TSH is low but the thyroid shows diffuse hyperplasia. Why?
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Q graves disease - library
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06-26-2005, 11:05 AM
TSH acts through TSH receptors. In grave's, there are autoantibodies bind to TSH receptors and keep stimulating the thyroid. That's why. In another words, the receptors are constantly on.
06-27-2005, 09:43 AM
..."Pathogenesis is immune, resulting from production of thyroid - stimulating Ig (TSI) and thyroid growth Ig, two autoantibodies that cause glandular hyperplasia and hormone production by binding to TSH receptors." -from Kaplan,
in other words, the thyroid gland is stimulated but not by THS but by those immunoglobulins.
06-27-2005, 11:12 AM
This is also an example of Type II noncytotoxic hypersensitivity
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