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genetic 14 - basicq
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05-08-2010, 10:22 PM
Two American Black individuals come to you for genetic counseling and are concerned about their risks of having children with Sickle Cell disease. They know that the risk of being a carrier in that population is one in ten. Which ONE of the following most closely approximates their risk for having a child with Sickle Cell disease?
A) 0 B) 1 in 4 C) 1 in 100 D) 1 in 400 E) 1 in 2500
05-08-2010, 10:34 PM
2pq=1/10
probablity dad will be a carrier=1/10 probablty dad will pass the disease causing gene along=1/2 probablity mom will be a carrier=1/10 probablity mom will pass the disease causing gene along=1/2 all of the above events are nonindependent hence multiply all= 1/10*1/2*1/10*1/2 which equals =1/400
05-09-2010, 04:12 AM
Probability of both parents being sickle cell trait is 0.1* 0.1 - 0.01
probability of child having SS disease ( Recessive disorder) , is 25% when two heterozygotes mate. Hence combined probability is 0.01 * 0.25 = 0.0025 or 1 in 400. |
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