Immuno Q. - iangel

[ArchivalUser]

A 4 y.o. boy is evaluated for a possible immunodef. he has suffered of bouts of diarrhea, and upper respiratory infections. Also has shown delayed development of protective responses to the standard childhood vaccinations.
normal number of b lymphocytes with IgM, and serum levels of monomeric IgA, IgE and IgG are normal. Which of the folllowing deficiencies could account for this findings?

A.- Absence of CD40L
B.- Absence of IL-2
c.- Abcense of J chains
D. Absense of IL-4
E.- Absence of tdt
F.- absence of Th2 cells.

[ArchivalUser]

AAAA Hyper IgM syndrome

[ArchivalUser]

a......

[ArchivalUser]

EEE??

[ArchivalUser]

Answer is C.

Indeed, most patients with this defect have hypermacrobulinemia, but absence of cd40 would affect production og IgG,IgA, IgE wich in this case are nl.