QQQ...Patho......................................3 - ariadnac06

[ArchivalUser]

40n YO male is hospitalized with unstable angina. On the 4 day of hospitalization he develops severe foot pain and right toe paleness. His laboratory testing is significant for platelets count of 60.000/mm3 Treatment with Argatrobin is initiated immediately. The drug used to treat this patient’s condition has which mechanism of action?

a)Bind to the thrombine site.
b)Block glutamate residue carboxilation
c)Block ADP receptor
d)Block GP IIb/IIIa surface receptor
e)Block phosphodiesterase


doitperfect1 Hi…right now UW... have a good night..

[ArchivalUser]

a....

[ArchivalUser]

aaa

[ArchivalUser]

aaa

[ArchivalUser]

answer is a

[ArchivalUser]

aaa

[ArchivalUser]

A.
Hi ariadna. I apologize for not answering you earlier, but I had to run an errand.
I'm doing fine by the grace of God. This is a long journey. You know what I mean.
Hope you are in good shape healthwise
Take care.

[ArchivalUser]

aaaa

[ArchivalUser]

AAAA is correct

I'm sorry for late reply…

The most common cause of thrombocytopenia in hospitalized patient is Heparin.
HIT Heparin Induce Thrombocytopenia: The immune system produce antibodies vs a complex, this complex is made of heparin + platelet facto IV + IgG Ab. The result is platelet activation leading to clot formation (paradoxical thrombosis) and low blood platelet levels leading to bleed. Rx Argatroban, Lepirudin, Danaparoid and Hirudin. They are direct thrombin inhibitors that bind to the thrombine active site. They don’t require antithrombin III for activation.