Pathology..... Q... - psychmledr

[ArchivalUser]

A 54-year-old man is admitted to the hospital with cough and dyspnea, which over a period of years has led to marked respiratory embarrassment and cyanosis. Chest x-ray film of the lungs shows bilateral lower lobe ground-glass infiltrates. Wedge biopsy of the lung demonstrates airspaces filled with macrophages containing lipid, periodic acid-Schiff (PAS)-positive granules, and lamellar bodies. There is an accompanying interstitial pneumonitis, hyperplasia of the septal lining epithelial cells, and desquamation of epithelial cells into alveoli. The lamellar bodies within the macrophages are composed of which of the following?

A. Amyloid

B. Calcitonin

C. Fibrin

D. Hemosiderin

E. Surfactant

[ArchivalUser]

ans is e

[ArchivalUser]

aaa

[ArchivalUser]

ee

[ArchivalUser]

Yep, answer is E.

[ArchivalUser]

lamellar bodies are in type 2 pneumocytes isnt it?
are you sure about the answer?

[ArchivalUser]

Yes, I have the answer as desquamative interstitial pneumonitis

[ArchivalUser]

thanks, can you give some detail on the explanation... (we trade )
lamellar bodies in macrophages can have surfactant...didn't know that :S

[ArchivalUser]

OK, here it is :
The disease is desquamative interstitial pneumonitis (DIP), which is
an idiopathic process related to idiopathic interstitial fibrosis. DIP may respond to steroid
therapy but may also progress to end-stage lung disease. The lamellar (or layered) bodies within macrophages contain surfactant derived from type II pneumocytes.
And now you know