01-22-2012, 09:05 AM
A young boy is being evaluated for a history of numerous fractures in the past. These fractures have resulted from minimal trauma. Examination of his peripheral blood reveals leukoerythroblastosis with numerous target cells. Which one of the following abnormalities is most characteristic of this boy's disease process?
a. Abnormal "tunneling" of osteoclasts into bone trabeculae
b. Abnormal osteoclasts that lack the normal ruffled border
c. Decreased calcification of osteoid matrix
d. Decreased cartilage cell proliferation at epiphyseal plates of long bones
e. Defective synthesis of type I procollagen
a. Abnormal "tunneling" of osteoclasts into bone trabeculae
b. Abnormal osteoclasts that lack the normal ruffled border
c. Decreased calcification of osteoid matrix
d. Decreased cartilage cell proliferation at epiphyseal plates of long bones
e. Defective synthesis of type I procollagen