NBME 1 block 2 25 - pathlova

[ArchivalUser]

A clone of cancer cells resistance to vincristine, doxorubicin and dactionomycin but not for MTX and various alkylating agents. mechanism of resistance most likely involve
A absence of superoxide dismutase
B altered DNA polymerase
C enhance drug transport out of cells
D inability to form polyglutamate
E increased DNAse

please explain

[ArchivalUser]

cc

[ArchivalUser]

Overexpression of a Surface Glycoprotein in cancer cells will pump the drugs out.
C is the correct answer.

[ArchivalUser]

thanx drfuture and nanomax.

[ArchivalUser]

cc..it is given in pharma kaplan anticancer drugs resistance table very very imp dat table..