NBME 4 sec 3 - go@usmle1

[ArchivalUser]

Healthy 80 y o man is scheduled for endoscopy for evaluation of rectal bleeding .A standard dose of MIdozolam is administered intravenously when the patient is admitted to endoscopy suite .A few min later ,he dev cyanosis and labored respirations and requires ventilation with an oxygenated resuscitation bag. An age-related incease in which of the following is the most likely cause of these adverse effect?
A) Enterohepatic recycling
B)Metabolite formation
C)Plasma protein in binding
D)Sensitivity to sedatives
E)Volume of distribution

[ArchivalUser]

D..

[ArchivalUser]

ya