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A pt is found to have a rare hemoglobin abnormality that decreases P50 for hemoglobin from 26 mmHg to 20 mmHg.This pt is most likely to develop which of the following ?
A-Hypoxia-induced hemolysis
B-Oxidant-induced hemolysis
C-Increased osmotic susceptibility of RBC
D-Polycythemia
E-Megaloblastic RBC change
kindly explain plz. Thanks
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A sickle cell anemia. Change in the structure causes decrease binding of O2??
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LOWERED P50 ..... it means the Hb Affinity for O2 has Increased
How does that apply to ur answer?
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DD
Lowered P50 means a shift to the left and increased affinity of Hb to O2.
Increased affinity means less oxygen delivered to the tissues, which is a state of hypoxia.
The patient will respond by producing more RBCs.
Thanks.
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Polycythemia incr number of RBC in c/o low p50 y not increase the size of RBC - megaloblasts
Plz can u explain
Thanx
