06-22-2006, 02:31 AM
11. Which is the likely consequence of impaired synthesis of Il-1
a. enhanced phagocytic activity of macrophages
b. enhanced production of antibody by B lymphocytes
c. impaired antigen processing by macrophages
d. impaired function of T lymphocytes
e. impaired production of leukotrienes by neutrophils
36. A clone of cancer cells is resistant to vincristine, doxorubicin, and dactinomycin but not to methotrexate and various alkylating agents. The mechanism of resistance involves
a. absence of superoxide dismutase
b. altered DNA polymerase
c. enhanced drug transport out of cell
d. inability to form polyglutamates
e. increased Dnase
30. A 5 year old boy with recurrent ear infection history receives his preschool booster immunization against diptheria, tetanus, pertussis. He is participating in a community sponsored study to determine the humoral immune response to tetanus toxoid (tt). His response is well below normal for age and sex matched children. Peripheral B lymphocyte count and T cell count and function are within the reference range. The antibody he makes is positive in both the passive hemagglutination and complement mediated lysis of tt-coated erythrocytes. His antibodies do not opsonize tt-coated latex particles for phagocytosis and do not directly precipitate tt efficiently. This child has a defect in
a. affinity maturation of immunoglobulins
b. immunoglobulin isotype switching
c. recombination of heavy chain variable region genes
d. recombination of light chain variable region genes
e. somatic mutation of immunoglobulin genes
7. A pharmaceutical company has developed a drug that prevents egress of Mg2+ from the NMDA receptor. What is the most likely effect of this rug in a patient with an acute stroke?
a. decreased risk for seizures due to hypomagnesemia
b. facilitation of Ca2+ entry into neuron and enhancement of excitotoxin-mediated cell death
c. hyperpolarization of membrane and counduction block
d. prevention of Ca2+ entry into neuron and reduction of excitotoxin-mediated cell death
rapid depolariziation of membrane with lowering of the seizure threshold
22. A 25 yo woman has generalized bone pain for 9 years. She has frequent episodes of loose bulky stools. Examination shows muscle weakness and distended abdomen. X ray films show generalized demineralization of bones, absence of lamina dura, and fracture like lines in the feet bones. What happens to Ca, Phosphorus, AP, and PTH?
26. A 62 yo man is brought to the doctor for evaluation of 6 mo history of progressively strange behavior. He has been impulsive and distractible, has stopped bathing and combing his hair. He is rude and unkempt. Occasionally, while eating he has stuffed food into this mouth with his fingers. He has mild problems with memor. His only medical problem is a 1 year history of htn controlled by atenolol. Neuro exam shows no focal signs but the grasp and snout reflexes are prominent.
a. arteriosclerosis
b. dementia, alzheimer™s type
c. huntington™s
d. normal aging
e. pick™s disease
33. A 55 yo man with patchy leukoplakia on anterior floor of mouth for 4 years. He now has a raised, firm white lesion in the same area. Examination of tissue obtained on biopsy of this new lesion is most likely to show
a. aphthous ulcer
b. burkitt™s lymphoma
c. candida
d. kaposi™s sarcoma
e. mixed parotid gladn tumor
f. squamour cell carcinoma
g. warthin™s tumor
41. A 4-year old girl is brought to the emergency department because of a 5-day history of fever, diffuse abdominal pain, nausea, vomitting, and diarrhea. Examination shows petechiae, hepatomegaly, and splenomegaly. Hemoglobin concentration is 8.7 g/dL and platelet count is 60,000/mm3. A perpheral blood smear shows erythrocyte fragmentation. Which of th following renal findings is most likely to be associated with her condition?
A) Glomerular crescent formation
B) IgG-associated glomerular basement membrane antibody
C) Membranoproliferative glomerulonephritis
D) Narrowing of the capillary wall by fibrin deposition
E) Periglomerular granuloma with giant cells
a. enhanced phagocytic activity of macrophages
b. enhanced production of antibody by B lymphocytes
c. impaired antigen processing by macrophages
d. impaired function of T lymphocytes
e. impaired production of leukotrienes by neutrophils
36. A clone of cancer cells is resistant to vincristine, doxorubicin, and dactinomycin but not to methotrexate and various alkylating agents. The mechanism of resistance involves
a. absence of superoxide dismutase
b. altered DNA polymerase
c. enhanced drug transport out of cell
d. inability to form polyglutamates
e. increased Dnase
30. A 5 year old boy with recurrent ear infection history receives his preschool booster immunization against diptheria, tetanus, pertussis. He is participating in a community sponsored study to determine the humoral immune response to tetanus toxoid (tt). His response is well below normal for age and sex matched children. Peripheral B lymphocyte count and T cell count and function are within the reference range. The antibody he makes is positive in both the passive hemagglutination and complement mediated lysis of tt-coated erythrocytes. His antibodies do not opsonize tt-coated latex particles for phagocytosis and do not directly precipitate tt efficiently. This child has a defect in
a. affinity maturation of immunoglobulins
b. immunoglobulin isotype switching
c. recombination of heavy chain variable region genes
d. recombination of light chain variable region genes
e. somatic mutation of immunoglobulin genes
7. A pharmaceutical company has developed a drug that prevents egress of Mg2+ from the NMDA receptor. What is the most likely effect of this rug in a patient with an acute stroke?
a. decreased risk for seizures due to hypomagnesemia
b. facilitation of Ca2+ entry into neuron and enhancement of excitotoxin-mediated cell death
c. hyperpolarization of membrane and counduction block
d. prevention of Ca2+ entry into neuron and reduction of excitotoxin-mediated cell death
rapid depolariziation of membrane with lowering of the seizure threshold
22. A 25 yo woman has generalized bone pain for 9 years. She has frequent episodes of loose bulky stools. Examination shows muscle weakness and distended abdomen. X ray films show generalized demineralization of bones, absence of lamina dura, and fracture like lines in the feet bones. What happens to Ca, Phosphorus, AP, and PTH?
26. A 62 yo man is brought to the doctor for evaluation of 6 mo history of progressively strange behavior. He has been impulsive and distractible, has stopped bathing and combing his hair. He is rude and unkempt. Occasionally, while eating he has stuffed food into this mouth with his fingers. He has mild problems with memor. His only medical problem is a 1 year history of htn controlled by atenolol. Neuro exam shows no focal signs but the grasp and snout reflexes are prominent.
a. arteriosclerosis
b. dementia, alzheimer™s type
c. huntington™s
d. normal aging
e. pick™s disease
33. A 55 yo man with patchy leukoplakia on anterior floor of mouth for 4 years. He now has a raised, firm white lesion in the same area. Examination of tissue obtained on biopsy of this new lesion is most likely to show
a. aphthous ulcer
b. burkitt™s lymphoma
c. candida
d. kaposi™s sarcoma
e. mixed parotid gladn tumor
f. squamour cell carcinoma
g. warthin™s tumor
41. A 4-year old girl is brought to the emergency department because of a 5-day history of fever, diffuse abdominal pain, nausea, vomitting, and diarrhea. Examination shows petechiae, hepatomegaly, and splenomegaly. Hemoglobin concentration is 8.7 g/dL and platelet count is 60,000/mm3. A perpheral blood smear shows erythrocyte fragmentation. Which of th following renal findings is most likely to be associated with her condition?
A) Glomerular crescent formation
B) IgG-associated glomerular basement membrane antibody
C) Membranoproliferative glomerulonephritis
D) Narrowing of the capillary wall by fibrin deposition
E) Periglomerular granuloma with giant cells