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[ArchivalUser]

A 25-year-old male with hypogonadism is treated with a synthetic androgen. Which of the following is activated by a synthetic androgen?
A.
Tyrosine kinase receptors
B.
G protein“coupled receptors
C.
Heat shock protein“bound receptors
D.
Muscarinic receptors
E.
Cytokine receptors

[ArchivalUser]

aa

[ArchivalUser]

The answer is: C

A variety of drugs that resemble steroid hormones in their structure can traverse cellular membranes and bind to specific cytoplasmic receptors that bind heat shock proteins. Among these are the synthetic androgens. These agents bind reversibly to the cytoplasmic receptor, causing release of the heat shock proteins, followed by an irreversible activation step. Next, the steroid-receptor complex enters the nucleus of the cell and regulates transcription of specific genes into RNA. Eventually, mRNA is formed and causes the synthesis of specific proteins that mediate the steroid response. The response occurs 30 min to several hours after administration of the drug, because a period of time is required for formation of new proteins in the cell.