04-11-2008, 02:03 PM
Guys i am really close to my exam .... I cant understand the mechanisms of antihyperlipidemics.... anyone please explain....
Thanks a lot in advance !
Thanks a lot in advance !
mechanism of antihypelipemics.... - mayflower224
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04-11-2008, 02:03 PM
Guys i am really close to my exam .... I cant understand the mechanisms of antihyperlipidemics.... anyone please explain....
Thanks a lot in advance !
04-11-2008, 06:04 PM
Ok
Lets keep it simple First Cholesterol & LDL Cholesterol LDL Acceptable <170 <110 Borderline 170 - 199 110 - 129 High 200 130 Plan: Whom to treat? No risk factors / LDL > 190 / Dietary Rx failed after 6 months : Drug Rx 2 or > risk factors / No atherosclerosis / LDL >160 : Drug Rx Atherosclerosis/ LDL >100 : Drug Rx 1. Bile Acid Binding Resins: Cholestyramine, Colestipol -- Indication: Increased LDL , Normal TG --MOA : Binds to bile acids in the gut, stops them going back to liver, excretes them in feces. --CI: Nil --SE: Constipation, 2. Nicotinic Acid : Niacin --Indication: Increased LDL/ Tg or both --MOA: Inhibits VLDL synthesis in liver by unknown mechanism --CI: active liver disease, active PUD --SE: cutaneous flushing, pruritis, abdomional discomfort, diarrhoea. 3. HMG Co A Reductase Inhibitors : Statins --Indiacation; Increased LDL --MOA: Inhibit HMG CoA Reductase the rate limiting enzyme in cholesterol synthesis --CI: Active liver disease, Pregnancy, lactation. Avoid in females of reproductive age & childeren --SE: rash, GIT, headache, insomnia, cancer risk ; except fluvastatin. 4. Fibric Acid Derivatives : Gemfibrozil, Clofibrate --Indication: Increased TG also when LDL & TG increase --MOA: Stimulated Lipoprotein Lipase ---> Breakdown of VLDL -----> Decreased LDL. --CI: Liver & Kidney disease, Gall bladder disease --SE: Mild GI discomfort most common 5. Probucol --Indication: Increased LDL --MOA: Increases catabolism of LDL --CI : Prolonged QT, recent MI --SE: Diarrheoea, flatulence, QT prolongation, Arrhthmias
04-11-2008, 06:12 PM
Dr pardha,
well formatted for quick review... i want to add two points Niacin cause Insulin resistance and cause hypotension. so if it is a diabaetic then ohd needs increasing and antihypertensive dose to be decreased ( hypothetical)
04-13-2008, 06:21 AM
Thanks a lot guys.....
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