09-10-2009, 09:31 AM
The greater proportion of the dose of a drug administered orally will be absorbed in the small intestine. However, on the assumption that passive transport of the nonionized form of a drug determines its rate of absorption, which of the following compounds will be absorbed to the least extent in the stomach?
A. Ampicillin (pKa = 2.5)
B. Aspirin (pKa = 3.0)
C. Warfarin (pKa = 5.0)
D. Phenobarbital (pKa = 7.4)
E. Propranolol (pKa = 9.4)
A. Ampicillin (pKa = 2.5)
B. Aspirin (pKa = 3.0)
C. Warfarin (pKa = 5.0)
D. Phenobarbital (pKa = 7.4)
E. Propranolol (pKa = 9.4)