05-11-2005, 04:24 AM
A 12-year-old girl is brought to a pediatrician because of a newly developed tendency to stumble and fall. Physical examination demonstrates a broad-based, slow, clumsy gait with a tendency to lurch from side to side. Several years later, the girl develops upper limb involvement manifested by clumsiness of fine movements and a coarse intention tremor. The patient eventually dies in the fourth decade of life, having experienced slowly progressive symptoms, and eventually becoming bedridden and developing kyphoscoliosis and foot deformities. Which of the following findings would be most likely at autopsy?
A. Atrophy of the caudate
B. Atrophy of the spinal cord
C. Depigmentation of the substantial nigra
D. Diffuse cortical atrophy
E. Selective frontal and temporal lobe atrophy
A. Atrophy of the caudate
B. Atrophy of the spinal cord
C. Depigmentation of the substantial nigra
D. Diffuse cortical atrophy
E. Selective frontal and temporal lobe atrophy