immuno q - dr73

[ArchivalUser]

A 23-year-old Caucasian female suffers from malar skin rash, proteinuria joint pain and generalized lymphadenopathy. Lymphocytes isolated from this patient show a mutated and functionally defective FAS gene product. Which of the following is most likely impaired in this patient as a result of the molecular defect?
A. Autoantigen sequestration in immune-privileged sites
B. Clonal deletion of activated T lymphocytes
C. Suppression by regulatory T lymphocytes
D. Functional inactivation of lymphocytes (anergy)
E. Affinity maturation of B lymphocytes

[ArchivalUser]

clonal deletion of activated T lymphocytes "B"
FAS ligand binds to FAS on T lymphocytes to cause their apoptosis, so no FAS ------ no apoptosis ------- no clonal deletion ------- unwanted T lymphocytes active in the body------ autoimmune disease.....