mech of action - lahemd

[ArchivalUser]

35 yr old man,who is recieving prophylactic drug therapy for +ve ppd,develops microcytic anemia.A bone marrow exam reveal numerous ring sideroblast.Which of the following biochemical reaction is dysfunctional in this pt.
A oxaloacetate..... malate
B methyl malonyl coa.....succinyl coa
C glucose 6 po4.......6 phosphogluconate
D oxidized glutathione.....reduced glutathione
E succinyl coa+ glysine....$ amino levulinic acid

[ArchivalUser]

It's E. Pt received Isoniazid,which caused B6 def. Vit B6 catalises first reaction of Heme synthesis.

[ArchivalUser]

Can you give short explan. for each answer choices?