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nbme 5 block 1 - cuma12
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06-04-2012, 11:04 AM
a man who has HIV had low CD4+ count. which has decreased?
a) IL2 b) antibody dependent cytotoxicity c) MPO d) NADPH oxidase e) TNF please explain why.
06-04-2012, 01:18 PM
no... according to the key the answer is A.
I was thinking either a or e. But I went with e because TH1 is part of the viral mediated pathway. So I was thinking TNF is decrease. But after looking it up - The two branches of TH1 are IL2 and IFNy. And interferon --> Mo. And I thought Mo release IL1 and TNF. but i guess that is with bacterial. So IL2 would be the correct answer.
06-04-2012, 01:39 PM
A
Decreaced Cd 4+---> Decreased TH1 (makes IL 2 required for cell differentiation and cloning) ------> Decreased IL2
11-01-2013, 02:51 AM
Decreased CD4+ lymphocyte should decrease Th1 & Th2 cells, right?
Both of them are CD4+. Both Th1 & Th2 cell secrete IL-2. And Th2 plays role in class switching of antibodies. But maybe antibodies are mainly produced from plasma cell / B cell. So ADCC may not be affected as much as IL-2. |
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