09-14-2009, 09:46 PM
A 72-year-old diabetic is transferred to your hospital
for fever and altered mental status in the late
summer. Symptoms started in this patient 1 week
prior to admission. On physical examination, the
patient was disoriented. There were no focal neurologic
findings. There was a fine rash on the patient™s
trunk. On oral examination, there were tongue
fasciculations. A lumbar puncture was performed
which showed a glucose of 71 and a protein of 94;
microscopy of the cerebrospinal fluid (CSF)
revealed 9 RBC and 14 WBC (21 P, 68 L, 11 H). The
creatinine phosphokinase was 506. An electroencephalogram
and MRI of the brain were normal.
1. What is the best interpretation of these
findings?
(A) The patient may have cryptococcal
meningitis.
(B) The patient may have disseminated
candidiasis.
© The patient may have West Nile virus.
(D) The patient may have Coccidioides immitis
infection.
(E) The patient may have rhinocerebral
mucormycosis.
2. What further diagnostic test is the most
appropriate?
(A) Perform a West Nile virus IgM on the
CSF.
(B) Perform a serum cryptococcal antigen.
© Perform C. immitis complement fixation
tests.
(D) Perform a sinus series.
(E) Perform a purified protein derivative
(PPD) skin test.
for fever and altered mental status in the late
summer. Symptoms started in this patient 1 week
prior to admission. On physical examination, the
patient was disoriented. There were no focal neurologic
findings. There was a fine rash on the patient™s
trunk. On oral examination, there were tongue
fasciculations. A lumbar puncture was performed
which showed a glucose of 71 and a protein of 94;
microscopy of the cerebrospinal fluid (CSF)
revealed 9 RBC and 14 WBC (21 P, 68 L, 11 H). The
creatinine phosphokinase was 506. An electroencephalogram
and MRI of the brain were normal.
1. What is the best interpretation of these
findings?
(A) The patient may have cryptococcal
meningitis.
(B) The patient may have disseminated
candidiasis.
© The patient may have West Nile virus.
(D) The patient may have Coccidioides immitis
infection.
(E) The patient may have rhinocerebral
mucormycosis.
2. What further diagnostic test is the most
appropriate?
(A) Perform a West Nile virus IgM on the
CSF.
(B) Perform a serum cryptococcal antigen.
© Perform C. immitis complement fixation
tests.
(D) Perform a sinus series.
(E) Perform a purified protein derivative
(PPD) skin test.