q............?? - tranqualizer

[ArchivalUser]

Four drugs produce the same therapeutic effect by the same mechanism, but each has a unique toxicity. When used at a
maximally effective therapeutic dose, the drug with which of the following sets of characteristics is most likely to have
the highest incidence of toxicity?
Median
effective dose
Toxic dose1/
effective dose99
(A) 0.5x 2.8
(B) 1x 2.1
© 5x 4.0
(D) 33x 3.0

PLS EXPLAIN...
Thanx

[ArchivalUser]

it's NBME question, isn't it??

[ArchivalUser]

i think the ans is A....
This is what i understand:

TI= Median lethal dose/median effective dose.

If TI is very high its safer
if TI is very low its toxic and unsafe.So in this question A is the least value so it is toxic

Correct me if i am wrong.