11-16-2011, 07:14 AM
A 48-year-old man has a painless enlarged axillary lymph node. Excisional biopsy shows replacement of nodal architecture by neoplastic follicles composed of small cleaved lymphocytes. Cytogeneic studies show a t(14;18). Alteration of which of the following processes most consistently underlies the pathogenesis of this lesion?
A) DNA repair
B) Growth factor production
C) Growth factor receptor regulation
D) Nuclear transcription factor expression
E) Regulation of apoptosis
A) DNA repair
B) Growth factor production
C) Growth factor receptor regulation
D) Nuclear transcription factor expression
E) Regulation of apoptosis