04-09-2012, 11:54 AM
I'll start it off.
One of the zumab drugs that is used to treat Multiple sclerosis. MOA works at the alpha 4 integrins. Know the function of integrins as well.
Rolling---> tight binding---> Diapedesis---> Migration------> Phagocytosis
[selectins] [LFA-1 Integrins] [PECAM-1] [IL-8 c5a, LTB4]
Drug is called natalizumab.
One of the zumab drugs that is used to treat Multiple sclerosis. MOA works at the alpha 4 integrins. Know the function of integrins as well.
Rolling---> tight binding---> Diapedesis---> Migration------> Phagocytosis
[selectins] [LFA-1 Integrins] [PECAM-1] [IL-8 c5a, LTB4]
Drug is called natalizumab.