Nephrogenic DI, Rx, plz explain. - imgpak

[ArchivalUser]

hydrochlorothiazide is used in nephrogenic DI, how??
plz explain....

[ArchivalUser]

its kinda strange but it diuresis to produce an anti diretuc effect. you lose plasma volume so your GFR falls due to lower plasma volume. it up regulates Aquaporin-2 (AQP-2) receptors, which act like a "ADH" analog. yeah. i don't get it either. but supposedly it works.

[ArchivalUser]

Thiazids act by Reducing diluting capacity of the nephrone.

An initial reduction of sodium reabsorption in the distal tubule increases sodium excretion and causes extracellular fluid volume contraction. As a result, the glomerular filtration rate decreases and the proximal tubular sodium and water reabsorption increases. Consequently, less water and sodium are delivered to the collecting tubules and, as a result, less water is excreted.

http://ndt.oxfordjournals.org/content/15....large.jpg

[ArchivalUser]

in another words

This decreases plasma volume, thus lowering GFR and enhancing the absorption of sodium and water in the proximal nephron. Less fluid reaches the distal nephron so overall fluid conservation is obtained.

[ArchivalUser]

thanks a lot maryam, for the detailed explanation......