Q@Qhemochromatosis? - cardio69

[ArchivalUser]

In pat with hemochromatosis, what happen to iron responsive element binding protein?

a)Active
b)Inactive


78sec

[ArchivalUser]

aa

[ArchivalUser]

Active

[ArchivalUser]

@ann17
The most “accurate” test for transferring saturation (several exist) is DIRECT most important one:
Colorimetric analysis SERUM iron COMbind w nephelometric assay of TRANSFERRIN
What’s that mean? ( & why Goli sad is the best)
Transferring Saturation = molar conc of iron /”twice” the molar conc of TRANSFERRIN. Hope we clear on that
The other less expensive/but also less robust methods to analyses of TIBC and Unbound iron:
Saturation of serum iron bind measured by = either TIBC (serum iron/TIBC) or by Unbound IBC [Serum iron/serum iron + Unbound IBC] -> norm for TS 15-45%.

In general term (hemochromatosis) when iron plenty (cell) take look at this hope that clear it up; and that trick the cell hope not you.
http://i.imgur.com/NTU2ZdR.png?1

The KEY central role in pathogenesis of inherited hemochromatosis-> *Hepcidin def* (including those cz by mutation HFE gene, HJB, TFR2 and hepcidin by itself

& MC 2ndry is transfusion WHY? 1mL of RBC -> contains ~ 1mg iron.

[ArchivalUser]

Thank you

[ArchivalUser]

Thanks.

[ArchivalUser]

@psych, My good wishes for you and family in spring!

[ArchivalUser]

Thank you, cardio. Wish you the very best

[ArchivalUser]

Thanks you so much cardio, I dint know a term transferring saturation exists........Thanks for the image too....