kindly explain this t(14;18)? - mojo2525

[ArchivalUser]

please explain this to me

when we say
t(8;14) we mean C-myc sitting on chromosome 8 comes and sits on chromosome 14

similarly
t(11;14) Cyc-D1 sitting on chrom 11 comes and sits on chrom 14

NOW, when we see Follicular lymphoma and we know TRANSLOCATION OCCURS IN A WAY THAT BCL-2 FROM CHROM 18 COMES AND SITS AGAIN ON CHROM 14

WHY ????????? Are we not calling it as translocation(18;14) ?????? why is it called t(14;18) ???

thankyou

[ArchivalUser]

It's simply a matter of convention and does not relate to the specifics of the how the translocation functions.

I wish there were a more satisfying answer, but that's it.

[ArchivalUser]

in case or M3 type of AML also there is retinoic acid receptor alpha from chromosme 17 is translocated to chromosome 15 PML gene but we write t(15;17) i guess we write smaller one first...

[ArchivalUser]

@youngdoc, fewa thanks