10-01-2016, 10:26 AM
what inheritance it has? mitochondrial or AR ?
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leigh syndrome - virgo32
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10-01-2016, 10:27 AM
in kaplan qbook, its is AR. in wikipedia it has mitochondrial , several others..
10-01-2016, 11:06 AM
it says 70 to 80% is nuclear dna mutation so i think its AR
10-01-2016, 03:50 PM
Depending on the mutated genome, Leigh syndrome can be inherited as a maternally inherited mitochondrial trait (mtDNA-encoded), as an autosomal recessive trait resulting from mutations in nuclear genes encoding mitochondrial respiratory chain complex subunits, complex assembly proteins, coenzyme Q10, mitochondrial targeted tRNA synthetases synthetases, and X-linked genes involved in complex I assembly factor (nuclear-encoded). Although most patients with Leigh syndrome have a mutation in nuclear DNA, about 25% have a mutation in mtDNA.
So in Short it has 3 patterns of inheritance. The most common is AR..! |
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