11-24-2019, 03:04 AM
A 35-year-old man comes to the physician because of a 3-year history of an enlarging nose, coarsening of his facial features, muscle weakness, and increased hand and foot size. Physical examination shows a large fleshy nose and prognatism. Serum studies show an increased insulin-like growth factor-I concentration. An MRI of the brain shows a pituitary adenoma. Morphologic analysis of a biopsy specimen of the tumor shows a densely granulated somatotroph adenoma. Further studies show that S subunit of G proteins in the tumor lack GTPase activity. The tumor cells in this patient most likely have an increased activity of wich of the following enzymes?
a) adenylyl cyclase
b) guanylyl cyclase
c) janus kinase
d) phospholipase C
e) Tyrosine kinase
the correct answer is A, but I can't understand why
a) adenylyl cyclase
b) guanylyl cyclase
c) janus kinase
d) phospholipase C
e) Tyrosine kinase
the correct answer is A, but I can't understand why
![Sad Sad](https://www.usmleforum.com/images/smilies/sad.png)