07-04-2012, 10:12 AM
A pt is admitted to the hospital with pneumonia due to gram negative bacteria.Antibiotic tobramycin is ordered.The Clearance (Cl) and Volume of Distribution (Vd) of tobramycin in this pt are 80 ml/min and 40 L, respectively.
If u wish to give this pt an IV of Loading Dose to achieve therapeutic plasma concentration of 4 mg/L rapidly, how much should be given ?
A- 0.1 mg
B- 10 mg
C- 115.2 mg
D- 160 mg
E- non of the above
If u wish to give this pt an IV of Loading Dose to achieve therapeutic plasma concentration of 4 mg/L rapidly, how much should be given ?
A- 0.1 mg
B- 10 mg
C- 115.2 mg
D- 160 mg
E- non of the above