12-09-2015, 09:37 AM
3) A 13-year-old boy is scheduled to receive chemotherapy for a leukemia that has the histologic features of malignant lymphocytes. This neoplasm is further typed for cell surface and intracellular markers specific for lymphocyte subsets. The neoplastic cells do not express the following markers: CD4, CD8, surface IgM, surface IgG, cytoplasmic IgM and μ-heavy chain, cytoplasmic IgG, and γ-heavy chain. The leukemic cells express class I MHC molecules and show rearrangement of the T-lymphocyte receptor β-chain gene D and J segments. Which of the following is the normal counterpart of these malignant lymphocytes?
A-Activated cytolytic effector T lymphocytes in the circulation
B-Mature IgM-secreting B lymphocytes in the lymph node
C-Mature immunoglobulin-secreting plasma cells in the lymph node
D-Pre-B lymphocyte progenitor of mature B lymphocytes in the bone marrow
E-T-lymphocyte thymocytes localized to the thymic cortex
A-Activated cytolytic effector T lymphocytes in the circulation
B-Mature IgM-secreting B lymphocytes in the lymph node
C-Mature immunoglobulin-secreting plasma cells in the lymph node
D-Pre-B lymphocyte progenitor of mature B lymphocytes in the bone marrow
E-T-lymphocyte thymocytes localized to the thymic cortex