11-28-2007, 09:53 AM
The answer is D.
Several drugs are associated with QT interval prolongation and the development of
polymorphic ventricular tachycardia (torsades de pointes). They include antiarrhythmic
agents (quinidine, sotalol, ibutilide, procainamide, amiodarone), antiinfective agents
(quinolones, erythromycin, clarithromycin, pentamidine), antiemetics (droperidol,
domperidone), antipsychotics (haloperidol, thioridazine), and other drugs (cisapride,
methadone). Prologation of the QT interval to more than 500 ms should prompt
consideration of drug alternatives. Unlike other antipsychotic medications, olanzapine
does not contribute significantly to QT prolongation, although caution is recommended
during concomitant treatment with drugs that do prolong the QT interval
Several drugs are associated with QT interval prolongation and the development of
polymorphic ventricular tachycardia (torsades de pointes). They include antiarrhythmic
agents (quinidine, sotalol, ibutilide, procainamide, amiodarone), antiinfective agents
(quinolones, erythromycin, clarithromycin, pentamidine), antiemetics (droperidol,
domperidone), antipsychotics (haloperidol, thioridazine), and other drugs (cisapride,
methadone). Prologation of the QT interval to more than 500 ms should prompt
consideration of drug alternatives. Unlike other antipsychotic medications, olanzapine
does not contribute significantly to QT prolongation, although caution is recommended
during concomitant treatment with drugs that do prolong the QT interval