02-18-2010, 11:54 AM
dna gyrase (topoisomerase II) introduce the negative supercoiling by cutting both strands and resealing
dna topoisomerase I can relax the supercoil, by cutting and resealing one strand
Quinolones inhibits dna topoisomerase II in prokaryotes
Etoposide, teniposide inhibits dna topoisomerase II in eukaryotes
That's my understanding; if I am wrong please correct me.
dna topoisomerase I can relax the supercoil, by cutting and resealing one strand
Quinolones inhibits dna topoisomerase II in prokaryotes
Etoposide, teniposide inhibits dna topoisomerase II in eukaryotes
That's my understanding; if I am wrong please correct me.