07-27-2010, 09:29 AM
@ Gusmle: Here is the given explanation
I was waiting to see if anyone else might comment on it.
The correct answer is E.
In order to achieve the desired drug plasma level rapidly, a loading dose can be given to
"load" the volume of distribution. Therefore, the only necessary information to answer this question is the volume of distribution, the desired plasma concentration, and how well the drug is absorbed into the body (bioavailability).
The equation to calculate loading dose is as follows:
(not given)
Note that clearance is important to calculate maintenance dose. In order to maintain target plasma levels, it is important to administer the amount of drug that is being cleared by the patient. Maintenance doses are typically given every half-life.
I was waiting to see if anyone else might comment on it.
The correct answer is E.
In order to achieve the desired drug plasma level rapidly, a loading dose can be given to
"load" the volume of distribution. Therefore, the only necessary information to answer this question is the volume of distribution, the desired plasma concentration, and how well the drug is absorbed into the body (bioavailability).
The equation to calculate loading dose is as follows:
(not given)
Note that clearance is important to calculate maintenance dose. In order to maintain target plasma levels, it is important to administer the amount of drug that is being cleared by the patient. Maintenance doses are typically given every half-life.