kathy q1 pathology - katy2011

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The histologic presence of
Lewy bodies can be seen in several disorders (Lewy body disorders) that differ
in the location where the Lewy bodies are found.
In classic Parkinson’s disease, Lewy bodies are found in the nigrostriatal system (producing
extrapyramidal movement disorder).
In Lewy body dementia, Lewy bodies are found in the cerebral cortex (producing dementia; this is the third most common cause of dementia).
In Shy-Drager syndrome, Lewy bodies are
found in sympathetic neurons in the spinal cord (causing autonomic dysfunction,
including orthostatic hypotension, impotence, abnormal sweat and
salivary gland secretion, and pupillary abnormalities). In Lewy body dysphagia,
Lewy bodies are found in the dorsal vagal nuclei (producing dysphagia).