09-01-2006, 06:02 PM
The answer is d. Sjögren™s syndrome is characterized
by dryness of the mouth (xerostomia) and eyes (keratoconjunctivitis
sicca). Secondary Sjögren™s syndrome is associated with rheumatoid
arthritis (RA), SLE, or systemic sclerosis. The primary form shows
increased frequency of HLA-DR3, while association with RA shows a positive
correlation with HLA-DR4. Anti-SSB antibodies are fairly specific, anti-
SSA less so, and both may occur in SLE; rheumatoid factor is often present.
Glomerular lesions are very rare, but a mild tubulointerstitial nephritis is
quite common and may result in renal tubular acidosis. In addition to the
usual dense, lymphoplasmacytic infiltrate of salivary glands, the lymph
nodes may show a œpseudolymphomatous appearance. True B cell lymphomas
have developed with increased frequency in Sjögren™s syndrome.
by dryness of the mouth (xerostomia) and eyes (keratoconjunctivitis
sicca). Secondary Sjögren™s syndrome is associated with rheumatoid
arthritis (RA), SLE, or systemic sclerosis. The primary form shows
increased frequency of HLA-DR3, while association with RA shows a positive
correlation with HLA-DR4. Anti-SSB antibodies are fairly specific, anti-
SSA less so, and both may occur in SLE; rheumatoid factor is often present.
Glomerular lesions are very rare, but a mild tubulointerstitial nephritis is
quite common and may result in renal tubular acidosis. In addition to the
usual dense, lymphoplasmacytic infiltrate of salivary glands, the lymph
nodes may show a œpseudolymphomatous appearance. True B cell lymphomas
have developed with increased frequency in Sjögren™s syndrome.