02-28-2008, 02:21 PM
Clomiphene binds the estrogen receptor. It typically acts as a partial antagonist; however, it can exhibit full antagonism or no effect at all. It stimulates ovulation in disorders of ovulation and in amenorrheic patients. In patients who fail to ovulate, it is suggested that clomiphene interferes with the negative feedback of endogenous estrogens, thereby increasing the release of LH and FSH by the pituatary.