let's put together all must know topics here - drvirgo

[ArchivalUser]

Mudassar, isnt testosterone, and not DHT necessary for development of wolfian duct structures inutero? and T is responsible for development of prostate, external genitalia and descend of testis

[ArchivalUser]

sorry i got carried away
testosterone level would be normal, FSH will be high.

[ArchivalUser]

lek yor are right DHT used for development of male external genitalia and also Prostate and male secondary sex charecteristics later in life.

While the normal development of the gonads, Wolffian ducts, testes, epididymis, vasa deferentia and seminal vesicles is testosterone-dependent and their development is not affected by 5-a-reductase deficiency.
thanks for correction n sorry for the reciprocality. Take care

[ArchivalUser]

Arya ,
you mean to say that in sertoli cell only syndrome-testosterone level -normal and FSH will be high.
I add little to it -patient 20-40 yrs old males and main complaint is infertility due to azoospermia.
For mudassar,DHT>>>prostate and external male genitalia. Testosterone>>>>>>>>male internal structures-epididymis,vas deferens,seminal vesicles.

[ArchivalUser]

hi everyone can put their important topics to be discussed here..please add to this thread by putting more topics from various subjects.take care.

[ArchivalUser]

As far as my understanding of sertoli cell only syndrome.

It is basically the replacement of normally functioning germinal epithelium in seminiferous tubules by immature or underdeveloped sertoli cells which can't produce inhibin so raised FSH. Nothing wrong wd ledig cells so normal Testosterone.

However there is a variant of SCOS which has decreased levels of FSH called immature variant. The immature variant is caused by a primary deficiency of FSH and LH production that begins in childhood and, as a result, maturation and renewal of germ cells does not occur.

[ArchivalUser]

lets compare high and low ald?

[ArchivalUser]

In Sertoli-cell-only syndrom
1-Plasma testosterone levels are typically normal.
2-Azoospermia and an elevated serum FSH level (>2-3 times reference range) indicate spermatogenic failure.
3-Azoospermia and a serum FSH level within the reference range suggest possible spermatogenic failure or an obstruction.
4-The serum FSH level is typically (90%) elevated. Elevations of greater than 2.5-3 0 times the reference range are diagnostic for spermatogenic failure.
5-Findings on testicular biopsy may include severe hypospermatogenesis, maturation arrest-spermatid stage, maturation arrest-spermatocyte stage, or Sertoli-cell-only (SCO) syndrome.