Archer question 286 - misshyd

[ArchivalUser]

d. low plt due to plt clumping seen on smear.

[ArchivalUser]

hey can any1 tell me the answer

[ArchivalUser]

so it was an error in blood collection???

[ArchivalUser]

pseudothrombocytopenia due to platelet clumping

[ArchivalUser]

good. Pseudo is common thrombocytopenia.

[ArchivalUser]

C

It is HITT treated with leupirdin .

[ArchivalUser]

it is DDDDDDDDD, FOR SURE

[ArchivalUser]

EDTA-Induced Platelet Agglutination (EIPA) (EDTA-platelet clumping):
EIPA is an in-vitro phenomenon due to the presence of naturally occurring autoantibody
against a cryptantigen on the GPIIb/IIIa platelet receptor. Under normal in vivo
conditions this antigen is not accessible for antibody binding (crypt or hidden antigen).
When calcium is chelated by EDTA, the GPIIb protein undergoes a structural change that
exposes the cryptantigen. The antibody can then bind to the exposed site and crosslink to
other platelets causing agglutination. The condition occurs in 0.1 to 2% of hospitalized
patients

[ArchivalUser]

answer is D... what shows in the slide in platelet clumping.. which can read as thromobocytopenia..so in real life manual counting is ordered and a repeat cbc is sent....

[ArchivalUser]

harddd ... d???