Molecular bio - saintdizzy

[ArchivalUser]

Approximately 10% of the patients with familial amyotrophic lateral sclerosis have an autosomal dominant mutation in copper/zinc superoxide dismutase gene SOD1. one therapy unde investigation for treatment is hammerhead ribozyme. which of the following best describes the mechanism by which a hammerhead ribozyme would be expected to treat ALS?

A. Ribozyme mediated degradation of mutant SOD1 mRNA
B. Ribozyme mediated destruction of mutant SOD1 gene
C. Ribozyme mediated inhibition of mutant SOD1 splicing
D. Ribozyme mediated inhibition of translation of mutant SOD1 mRNA
E. Ribozyme mediated inhibition of transcription from mutated SOD1 gene
F. Ribozyme mediated targeting of mutant SOD1 protein for destruction by the proteosome

[ArchivalUser]

self-cleaved RNA. In the natural state - ss RNA and in the absence of protein enzymes - autocatalitic. The hammerhead ribozyme carries out a very simple chemical reaction that results in the breakage of the substrate strand of RNA, specifically at C17.

Just ribozyme - is ribonucleic acid enzyme or RNA enzyme or catalytic RNA. They catalyze hydrolysis of own phosphodiester bonds or in other RNA. So hammerhead is distractor
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So I think it's A

Plz post more molecular bio Qs,and tell where do u find them?

[ArchivalUser]

AA

[ArchivalUser]

AA.

Thanks for the qs.