Hematology Q - usmlex123

[ArchivalUser]

Hemoglobin Electrophoresis is performed on a 23 yr old with sickle cell disease. He denies taking any medications at home. Lab studies reveal-

Mean Corpuscular Volume- 114
Reticulocytes- 5.0%

This patients markedly increased macrocytosis is most likely caused by which of the following?
a) Extramedullary erythropoiesis
b) Folic acid deficiency
c) Myelodysplastic syndrome
d) Iron overload
e) Liver disease


Explain your pick.

[ArchivalUser]

Mean Corpuscular Volume- 114 Macrocytic anemia
b) Folic acid deficiency

[ArchivalUser]

@Captan
Correct "B"

But if your reasoning is only Macrocytic Anemia of 114, you would also need to rule out Extramedullary erythropoiesis that exhibits mild macrocytic anemia as well.
You're almost there- just need to think 1 step ahead.