04-03-2007, 05:24 PM
A 45-year-old woman is undergoing chemotherapy for chronic lymphocytic leukemia. She begins to develop progressive neurological impairment, including weakness of the right leg and double vision. Imaging demonstrates extensive scattered areas of asymmetric demyelination involving both the cerebrum and cerebellum. The patient becomes more unresponsive and succumbs to a secondary unrelated infection. At autopsy, microscopic examination of the brain demonstrates viral inclusion bodies within oligodendrocytes and bizarre giant astrocytes. Which of the following is the most likely diagnosis?
(A) Acute disseminated encephalomyelitis
(B) Central pontine myelinolysis
© Multiple sclerosis
(D) Progressive multifocal leukoencephalopathy
(E) Subacute sclerosing panencephalitis
(A) Acute disseminated encephalomyelitis
(B) Central pontine myelinolysis
© Multiple sclerosis
(D) Progressive multifocal leukoencephalopathy
(E) Subacute sclerosing panencephalitis